A novel un-catalyzed and solvent-free method for the synthesis of 2-thioxothiazolidin-4-ones

During the last few decades, Multi-Component Reactions (MCRs) have been studied as a facile route to assemble complex important structures in a small number of steps, while reducing production costs and environmental concerns. As a result, MCRs have attracted growing attention, leading to the development of new, highly selective methods for the synthesis of bioactive compounds such as natural products, drugs and agrochemicals [1]. Rhodanines, an important 5-membered class of heterocyclic compounds, represent a privileged scaffold in drug discovery. Rhodanine based compounds and their analogues have an inherent tendency towards pharmacological and therapeutic activities, such as antibacterial, antifungal, antiviral, antimalarial, antitumor, anti-in ammatory and cardiotonic activities [2]. 2-Thioxothiazolidin-4-ones are classically prepared [3] by the reaction of N-alkylthiocarbamate (formed in situ from an amine and carbon disul-